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Unfortunately, the data obtained at the test site is often only available to researchers who are directly involved in a particular experiment. The measured and simulated data as well as research results obtained from them are highly relevant as they improve the general understanding of geological processes, for example in the context of radioactive waste disposal. At the Mont Terri URL in Switzerland, international research groups conduct numerous experiments in parallel. Underground Research Laboratories (URLs) allow geoscientific in-situ experiments at large scale. In doing so, the composite 4-D wound microenvironment platform provides multi-level insights into the structure of mixed-species biofilms, which we incorporate into the current understanding of P. aureus biofilms across multiple levels of organization such as aggregate dimensions and biomass thickness, species co-localization and organization within the biomass, overall biomass composition and interspecies interactions. We leveraged this composite 4-D wound microenvironment to probe the structure of mixed-species P. We have built a four-dimensional (4-D) wound microenvironment consisting of a 3-D host cell scaffold of co-cultured human epidermal keratinocytes and dermal fibroblasts, and an in vitro wound milieu (IVWM) the IVWM provides the fourth dimension that represents the biochemical and nutrient profile of the wound infection state. Therefore, composite in vitro models that bring together key features of the wound microenvironment could provide unprecedented insights into the structure and organization of mixed-species biofilms. aureus biofilms, with species-dependent localization patterns and interspecies interactions.
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On the other hand, biomimetic in vitro systems, such as host cell surfaces and simulant media conditions, albeit reductionist, have been shown to support the co-existence of P. aureus in wounds, they are limited in their ability to provide a detailed characterization of biofilm structure and organization across the host-microbial interface. While clinical studies, in vivo and ex vivo model systems have provided insights into the distribution of P. Given this, the interplay across host and microbial elements, including the biochemical and nutrient profile of the microenvironment, likely influences the structure and organization of wound biofilms. aureus organization in the wound bed.īiofilms in wounds typically consist of aggregates of bacteria, most often Pseudomonas aeruginosa and Staphylococcus aureus, in close association with each other and the host microenvironment.
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Biofilms in wounds typically consist of aggregates of bacteria, most often Pseudomonas aeruginosa and Staphylococcus aureus, in close association with each other and the host microenvironment.